Ekulweni nalolu bhubhane ekuqaleni kuka-2020, ezinsukwini ezingama-35 nje kuphela, kwasungulwa imodeli yegundane le-ACE2, futhi umcwaningi u-Guangming Wu nozakwabo beCentre for Cell Fate and Lineage Research (CCLA) e-Bio-Island Laboratories benze ngempumelelo impumelelo enkulu kusetshenziswa ubuchwepheshe be-stem cell ukudala "ukulwa ne-New Coronary Pneumonia".Isimangaliso sejubane ekuhlaselweni okuphuthumayo.
Ukuhlolwa okungazelelwe
Ngo-Agasti 2019, u-Wu Guangming, umcwaningi wesikhathi eside emkhakheni wokuthuthukiswa kombungu, wabuyela e-Guangzhou esuka eJalimane ukuyojoyina iqoqo lokuqala "leSifundazwe sase-Guangdong ukuze akhe ithimba likazwelonke lokugcina indawo yaselabhorethri" ye-Bio-Island Laboratory, okuyi- I-Guangzhou Guangdong Laboratory ye-Regenerative Medicine kanye Nezempilo.
Ayengakulindele ukuthi ngeke kuthathe isikhathi eside ngaphambi kokuthi abhekane novivinyo olungalindelekile lokuqubuka okusha kwe-crown pneumonia.
“Umkhakha wocwaningo engisebenza kuwo empeleni awuhlangene nezifo ezithathelwanayo, kodwa ngenxa yalolu bhubhane oluzayo, ngemuva kokuthola ukuthi uMnyango wezeSayensi nobuChwepheshe esifundazweni saseGuangdong ususungule iphrojekthi ekhethekile yocwaningo oluphuthumayo mayelana nomqhele omusha. ubhubhane lwe-pneumonia, ngazibuza ukuthi yini engingayenza ukulwa nalolu bhubhane lapho izwe lonke lisebenza ngokubambisana. "
Ngokuqondisisa, uWu Guangming uthole ukuthi izinhlobo zezilwane ezenziwe abantu zidingeka ngokushesha ukuze kuhlonzwe futhi kulashwe i-coronavirus entsha kanye nokulawula kwayo isikhathi eside.Okubizwa ngokuthi imodeli yezilwane eyenziwe ngabantu ukwenza izilwane (izinkawu, amagundane, njll.) ezinezici ezithile zezicubu zomuntu, izitho, namaseli ngokuhlelwa kwezakhi zofuzo nezinye izindlela zokwakha amamodeli ezifo, ukufunda izindlela ezithinta izifo zabantu futhi uthole. izixazululo ezingcono kakhulu zokwelapha.
Ukuhlasela kwaqedwa ezinsukwini ezingu-35
UWu Guangming utshele intatheli ukuthi kwakunamamodeli amaseli e-in vitro kuphela ngaleso sikhathi futhi abantu abaningi babekhathazekile.Waba neminyaka eminingi yokuhlangenwe nakho ocwaningweni lwezilwane ezishintshashintshayo futhi wayenekhono kubuchwepheshe besinxephezelo se-tetraploid.Omunye wemibono yakhe yocwaningo ngaleso sikhathi kwakuwukuhlanganisa ubuchwepheshe be-embryonic stem cell kanye nobuchwepheshe besinxephezelo se-embryonic tetraploid ndawonye ukuze kusungulwe amamodeli amagundane angabantu, futhi kwakukhuthaza ukuthi iCentre for Cell Fate and Genealogy Research e-Bio Island Laboratories ibe nobuchwepheshe obuphambili be-stem cell. , futhi kwakubonakala sengathi zonke izimo zangaphandle zase zivuthiwe.
Ukucabanga kuyinto eyodwa, ukwenza kungenye into.
Kunzima kangakanani ukwakha imodeli yegundane elisebenzisekayo?Ngaphansi kwezinqubo ezijwayelekile, kungathatha okungenani izinyanga eziyisithupha futhi kudlule inqwaba yezinqubo zamaphutha.Kepha lapho kuqubuka ubhubhane oluphuthumayo, umuntu udinga ukujaha isikhathi futhi abambelele kumephu.
Leli thimba lasungulwa ngokuzikhandla ngoba iningi labantu lalivele ligoduke ngoNyaka Omusha WaseShayina.Ekugcineni, abantu abayisishiyagalombili abasala e-Guangzhou batholakala ngaphansi kwenhlangano ye-Centre for Cell Fate and Genealogy Research ukuze bakhe ithimba lesikhashana lokuhlasela imodeli yamagundane.
Kusukela ekwakhiweni kwephrothokholi yokuhlola ngoJanuwari 31 kuya ekuzalweni kwesizukulwane sokuqala samagundane enziwe abantu ngoMashi 6, ithimba lafeza lesi simangaliso socwaningo lwesayensi ngezinsuku ezingama-35 kuphela.Ubuchwepheshe obujwayelekile budinga ukuxuba amaseli esiqu segundane kanye nemibungu ukuze kutholwe amagundane e-chimeric, futhi kuphela uma ama-stem cells ehlukana abe amaseli amagciwane bese ehlangana namanye amagundane ukuze adlulisele izakhi zofuzo esizukulwaneni esilandelayo samagundane lapho kungabhekwa njengempumelelo.Amagundane enziwe abantu avela ku-CCLA azalelwe ukuthola amagundane angqongqozayo ngesikhathi esisodwa, athola isikhathi esibalulekile futhi onga abasebenzi kanye nezinsizakusebenza zokulwa nobhubhane.
U-Wu Guangming emsebenzini Isithombe/sinikezwe oxoxwa naye
Zonke zisebenza isikhathi esengeziwe
U-Wu Guangming uvumile ukuthi ekuqaleni, ayikho inhliziyo yomuntu eyayinephansi, futhi ubuchwepheshe be-tetraploid ngokwabo babunzima kakhulu, ngezinga lempumelelo elingaphansi kuka-2%.
Ngaleso sikhathi, bonke abantu babezinikele ngokugcwele ocwaningweni, kungakhathaliseki ukuthi kunini nasebusuku, ngaphandle kwezinsuku zokusebenza nangezimpelasonto.Nsuku zonke ngo-3:00 noma 4:00 ekuseni, amalungu eqembu ayexoxa ngentuthuko yosuku;baxoxa kwaze kwasa base bebuyela kolunye usuku locwaningo.
Njengomholi wezobuchwepheshe wethimba labacwaningi, u-Wu Guangming kufanele alinganisele izici ezimbili zomsebenzi - ukuhlela izakhi zofuzo nesiko lombungu - futhi kufanele alandele zonke izinyathelo zenqubo yokuhlola futhi axazulule izinkinga ngesikhathi, okuyinto ecindezela kakhulu kunalokho umuntu angakwenza. cabanga.
Ngaleso sikhathi, ngenxa yeholide loMkhosi waseNtwasahlobo kanye nobhubhane, zonke izinto ezazidingeka zazingasekho, futhi kwakudingeka sithole abantu yonke indawo ukuze sibaboleke.Umsebenzi wansuku zonke kwakuwukuhlola, ukuhlola, ukuthumela amasampula kanye nokubheka izinto ezivuselelayo.
Ukuze kusheshiswe isikhathi, ithimba locwaningo liphule isimo esijwayelekile senqubo yokuhlola, kuyilapho ukulungiswa kwangaphambi kwesikhathi kwesinyathelo ngasinye sokuhlola esilandelayo.Kodwa lokhu kusho nokuthi uma kukhona okungahambi kahle ezinyathelweni ezedlule, izinyathelo ezilandelayo zilungiselelwa ize.
Kodwa-ke, izivivinyo zebhayoloji ngokwazo ziyinqubo edinga ukuzama okungapheli kanye namaphutha.
U-Wu Guangming usakhumbula ukuthi kanye, i-in vitro vector yasetshenziselwa ukufakwa ngokulandelana kwe-DNA yeselula, kodwa ayizange isebenze, ngakho kwadingeka ukuthi alungise ukugxiliswa kwe-reagent kanye neminye imingcele kaningi futhi akwenze kaningi kuze kube yilapho. isebenzile.
Umsebenzi wawunzima kakhulu, wonke umuntu wayexakeke, amanye amalungu ayenamabhamuza emlonyeni, amanye ayesekhathele angaze aqosheme phansi ukuze akhulume ngoba ayengakwazi nokusukuma.
Ukuze aphumelele, u-Wu Guangming, nokho, waze wathi ube nenhlanhla yokuhlangana neqembu labadlali abavelele eqenjini, futhi kube kuhle ukuqeda ukwakhiwa kwemodeli yegundane ngesikhathi esifushane kangaka.
Ngisafuna ukuthuthuka
NgoMashi 6, amagundane esizukulwane sokuqala se-17 azalwa ngempumelelo.Kodwa-ke, lokhu kungachazwa kuphela njengesinyathelo sokuqala sokuphothulwa komsebenzi, okwalandelwa ngokushesha inqubo yokuqinisekisa eqinile kanye nokuthunyelwa kwamagundane enziwe abantu elebhu ye-P3 ukuze kuhlolwe ngempumelelo igciwane.
Kodwa-ke, uWu Guangming uphinde wacabanga ngokuthuthuka okwengeziwe kumodeli yegundane.
Utshele izintatheli ukuthi u-80% weziguli ezine-COVID-19 zine-asymptomatic noma zigula kancane, okusho ukuthi zingathembela ekugomeni kwazo ukuze zilulame, kanti ezinye ezingama-20% zeziguli ziba nesifo esibi kakhulu, ikakhulukazi kwasebekhulile noma labo abanezifo ezikhona. .Ngakho-ke, ukuze kusetshenziswe ngokunembe nangempumelelo amamodeli egundane ocwaningweni lwe-pathology, izidakamizwa, kanye nomgomo, ithimba liqondise amagundane enziwe abantu kanye nokuguga ngaphambi kwesikhathi, isifo sikashukela, umfutho wegazi ophakeme, nezinye izinhlobo zezifo eziyisisekelo ukuze kusungulwe imodeli yegundane lesifo esibi.
Uma ebheka emuva emsebenzini onzima, uWu Guangming uthe uyaziqhenya ngeqembu elifana naleli, lapho wonke umuntu eqonda ukubaluleka kwalokho abakwenzayo, benezinga eliphezulu lokuqwashisa, futhi basebenza kanzima ukuze bathole imiphumela enjalo.
Izixhumanisi zezindaba ezihlobene:"I-Guangdong War Epidemic To Honor Heroes" Iqembu lika-Wu Guangming: izinsuku ezingama-35 zokusungula imodeli yegundane elenziwe umuntu le-ACE2 (baidu.com)
Isikhathi sokuthumela: Aug-02-2023