Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ukuhlaziywa kokuphumelela kwe-Pharmacological

i-pharmacological-efficacy-analysis-product

Ukuhlaziywa kokuphumelela kwe-Pharmacological kubhekisela ekuhloleni nasekuhlolweni kokusebenza kwezidakamizwa ekufezeni imiphumela yazo yokwelapha ehlosiwe.Kuyisinyathelo esibalulekile ohlelweni lokuthuthukiswa kwezidakamizwa futhi sicacisa izinzuzo nemikhawulo engaba khona yenhlanganisela yemithi.

Ngokuhlaziya ukusebenza kahle kwemithi, abacwaningi bahlose ukunquma ukuthi umuthi uxhumana kahle kangakanani nesamukeli sawo esiqondiwe noma uhlelo lwebhayoloji, okuholela ekuphenduleni okufiswayo kokuphila.

I-MingCeler ingahlinzeka ngamamodeli ahlukahlukene egundane afanelekile afana nokuguquguquka komuntu kanye nofuzo ngokwezidingo zamakhasimende, ikakhulukazi amamodeli wezifo ezihlelwe ngofuzo ezingalingisa ngokunembile inqubo yokuthuthukiswa kwezifo zabantu, ezingasetshenziswa ukuhlola nokuhlaziya ukusebenza kahle kwezidakamizwa kanye ngcono izinga lempumelelo yokuthuthukiswa kwezidakamizwa emisha.

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Ukuhlolwa kwenkomba ye-biochemical yegazi

-I-In vitro yokukhipha noma ukuvezwa ngokweqile kwezakhi zofuzo emigqeni yamaseli akhiwe ngofuzo

-In vivo Khipha noma ukuvezwa ngokweqile kofuzo oluqondiwe kumamodeli wamagundane

-Ukuhlolwa kokusebenza kwe-vivo okuhlanganisa ukukhula kwesimila, ukumetastasis, njll.·

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Ukuziphatha Kwezilwane

·Ukuhlolwa kwekhono lokufunda nenkumbulo:

I-maze yamanzi kaMorris (inkumbulo yokufunda yendawo, inkumbulo yokusebenza, inkumbulo yereferensi, ukufunda okuhlanekezelwe, inkumbulo encike kwi-hippocampal);I-Barnes Maze (ukufunda kwendawo kanye nenkumbulo);

Ukwesaba Okunemibandela:

Inkumbulo engokomzwelo, ukwesaba okuhambisana ne-hippocampal okuncike ku-hippocampal, ukwesaba okunesimo okungeyona i-hippocampal, inkumbulo yesikhathi eside, inkumbulo yesikhashana, inkumbulo encike ku-amygdala, kanye nokusabela kokwesaba.

·Ukuhlolwa Kokuziphatha Kokukhathazeka:

Elevated Cross Maze, Conditioned Fear Test, Absence Field Behavior Test, Startle Response, No Social Interaction Behaviour.

·Ukuhlolwa kokuziphatha kokucindezeleka:

Ukuhlolwa kwe-hypophagia kwemvelo okusha, ukuhlolwa komsila olengayo, ukuhlolwa kokubhukuda okuphoqelekile, ukuhlolwa kokuziphatha kokungabi khona emsebenzini, ukuhlolwa kokuziphatha kokusebenzelana komphakathi, kanye nokuthola ukungabi namandla.

·Ukuhlolwa kokuziphatha okuhlobene nobuhlungu:

Ukukalwa kobuhlungu ngepuleti elishisayo, ukukalwa kobuhlungu ngokunyakaziswa komsila (ukushisa kwe-infrared nokucindezela kubangelwa)

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Ireferensi

[1]Othman MZ,Hassan Z, Che Has AT.I-Morris water Maze: ithuluzi eliguquguqukayo nelifanele lokuhlola ukufunda kwendawo kanye nenkumbulo.Exp Anim.2022 Aug 5;71(3):264-280.doi:10.1538/expanim.21-0120.Epub 2022 Mar 18. PMID: 35314563;I-PMCID: PMC9388345.

Xhumana nathi

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