Iseli kuthiwa liyi-homozygous yofuzo oluthile lapho ama-allele afanayo ofuzo ekhona kuwo womabili ama-chromosome angama-homologous.
Imodeli yegundane i-homozygous iyisilwane zelebhu esivame ukusetshenziswa esihlelwe ngokofuzo ukuze sibe namakhophi amabili afanayo ofuzo oluthile.Le modeli isetshenziswa kakhulu ophenyweni lwesayensi ukuhlola ukuphazamiseka kofuzo nezifo ezahlukahlukene.
Ngobuchwepheshe bendabuko, kuthatha okungenani izizukulwane ezi-2-3 zokuzalanisa nokuhlolwa ukuze kutholwe amagundane angama-homozygous kumagundane axhasa ngemali, abiza ingqikithi yezinyanga eziyi-10-12 ngezinga eliphansi lempumelelo.