Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ukwenza ngokwezifiso Igundane le-Quickmice™ elisheshayo le-KI

i-quickmice-fast-ki-mouse-customization-product

I-Knock-in (Knock-in, KI) indlela esebenzisa ukuhlanganiswa kabusha kwe-homologous kwezakhi zofuzo ukuze kudluliselwe isakhi sofuzo sangaphandle sibe ngokulandelana kwe-homologous kuseli ne-genome, futhi zithole ukubonakaliswa kahle kuseli ngemva kokuhlanganiswa kabusha kofuzo.

Kuthatha izinyanga ezingu-5-6 ukuthola amagundane e-heterozygous asusiwe ne-Neo kanye nengqikithi yezinyanga ezingu-10-12 ukwakha amamodeli egundane e-KI homozygous ngezinga eliphansi lempumelelo kusetshenziswa amasu endabuko, ngoba lezi zindlela zine-chimera positivity ephansi futhi zidinga ukukhwelana ngegundane ukuze thola amagundane e-heterozygous asusiwe e-Neo, bese uzalanisa amagundane azalwa yi-heterozygous izizukulwane ezi-2-3 ukuze uthole amagundane e-KI e-homozygous.

Isizukulwane esisha se-Rapid Mouse Preparation Technology

I-TurboMice™

Singakunikeza ngokushesha amamodeli egundane e-KI homozygous ngokusebenzisa ubuchwepheshe be-TurboMice™ ukuze sithuthukise izinga lempumelelo.

Ngokusekelwe ohlelweni oluhle kakhulu lokuhlela izakhi zofuzo ososayensi bethu, singaqedela ukuhlolwa kwamaseli e-embryonic stem phakathi kwezinsuku ezingu-3-5, bese sakhe umbungu we-tetraploid.Ngemuva kokubeletha komama, amagundane e-homozygous humanized angatholakala phakathi nezinyanga ezingu-2-4, angasindisa izinyanga ezingu-7-8 kumakhasimende.

Okuqukethwe Kwesevisi

Inombolo Yesevisi. Izinkomba zobuchwepheshe Okuqukethwe kokudiliva Umjikelezo wokulethwa
I-MC002-1 ubude bofuzo olulodwa <5kb 3-9 KI homozygous amagundane abesilisa 2-4 izinyanga
I-MC002-2 ubude bofuzo olulodwa <5kb 10-19 KI amagundane wesilisa homozygous 2-4 izinyanga
I-MC002-3 ubude bofuzo olulodwa <5kb 20 KI homozygous amagundane abesilisa 3-5 izinyanga
I-MC002-4 ubude bofuzo olulodwa buyi-5kb-10kb 3-9 KI homozygous amagundane abesilisa 3-4 izinyanga
I-MC002-5 ubude bofuzo olulodwa buyi-5kb-10kb 10-19 KI amagundane wesilisa homozygous 3-4 izinyanga
I-MC002-6 ubude bofuzo olulodwa buyi-5kb-10kb 20 KI homozygous amagundane abesilisa 3-5 izinyanga

Xhumana nathi

Sicela uxhumane nathi ku:

1) Sicela ulande futhi ugcwalise ifomu elingezansi《Ifomu lesicelo sekhotheshini》, bese uyithumela nge-imeyili kuMingCelerOversea@mingceler.com;

2) ITe: +86 181 3873 9432;

3) I-LinkedIn: https://www.linkedin.com/company/ ukuthengar/

Ifomu lesicelo sekhotheshini.docx

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